A retrospective cohort study consisting of patients with delirium secondary to second generation antipsychotics reported to a single poison center was conducted. What percentage had a positive response to physostigmine and what percent had an adverse reaction?
A positive response was noted in 82.8% [95 percent confidence interval 68.9–83.6 percent]. Adverse events were noted in 2.9%.
Arens, A. M., Sheikh Said, H., Driver, B. E., & Cole, J. B. (2024). Physostigmine reversal of delirium from second generation antipsychotic exposure: a retrospective cohort study from a regional poison center. Clinical Toxicology, 1–5. https://doi.org/10.1080/15563650.2024.2373850
Contributed by Kristine Nanagas, MD
Posted in Question Of The Day