What adverse drug effect from trimethoprim-sulfamethoxazole has recently been associated with HLA-B*07:02 and HLA-C*07:02?
All cases of respiratory failure in association with trimethoprim-sulfamethoxazole were heterozygous or homozygous for the above haplotype. Carmparison to control suggests that HLA-B*07:02 and HLA-C*07:02 are necessary for a patient to develop respiratory failure due to TMP-SMX
Goldman JL, Miller JO, Miller N, Eveleigh R, Gibson A, Phillips EJ, Pastinen T. HLA-B*07:02 and HLA-C*07:02 are associated with trimethoprim-sulfamethoxazole respiratory failure. Pharmacogenomics J. 2022 Mar;22(2):124-129. doi: 10.1038/s41397-022-00266-8. Epub 2022 Feb 16. PMID: 35169303; PMCID: PMC9125581.
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