Historical QOD 1/22/2009: Describe the mechanism of action of sitagliptin for use in type II diabetes mellitus.
Sitagliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitor. By inhibition of DPP-4, sitagliptin enhances post-prandial levels of active glucagon-like peptide-1 (GLP-1), subsequently leading to a rise in insulin release and a decrease in glucagon.
Zerilli T. Pyon EY. Sitagliptin phosphate: a DPP-4 inhibitor for the treatment of type 2 diabetes mellitus. Clinical Therapeutics. 29(12):2614-34, 2007 Dec.
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