Chronic, supratherapeutic use of Trimethoprim/Sulfamethoxazole is associated with which adverse effect?
“Use of BACTRIM at high doses and/or for extended periods of time may cause bone marrow depression manifested as thrombocytopenia, leukopenia and/or megaloblastic anemia. If signs of bone marrow depression occur, the patient should be given leucovorin 5 to 15 mg daily until normal hematopoiesis is restored.”
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/017377s074lbl.pdf
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