What already FDA approved compound maybe a potential antidote for hepatotoxicity from Amanita phalloides?
According to the cited reference, indocyanine green has been shown in vitro and in mice models to decrease update of Alpha amanitin into cells and decrease liver damage.
Wang, B., Wan, A.H., Xu, Y. et al. Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity. Nat Commun 14, 2241 (2023). https://doi.org/10.1038/s41467-023-37714-3
Contributed by Samuel Cory, DO, , PGY-3 emergency medicine resident at St. Rita’s Medical Center
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