What is a risk factor for liver injury due to long-term nitrofurantoin exposure?
Liver injury associated with long term exposure from nitrofurantoin leads to fibrosis, cirrhosis and liver failure. HLA DRB1*11:04 is a risk factor for liver injury after long term use of nitrofurantoin.
Chalasani N et al. Clinical features, outcomes, and HLA risk factors associated with nitrofurantoin-induced liver injury. J Hepatol 2023; Feb 78(2): 293-300. PMID 36152763
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