In a study of pediatric Han Chinese patients, which risk factor was associated with development of valproate toxicity (liver injury): age, sex, dose of valproate, or valproate concentration?
Male patients had a higher percentage of liver injury (58.9%) compared to female patients (41.1%). Male patients’ ALT and AST were approximately 42% and 30% greater than in female patients (P ˂ 0.05).
Ma L, Wang D. Sex differences in the susceptibility to valproic acid-associated liver injury in epileptic patients. Clinical Toxicology. 2024 Mar 1:1-6.
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