What is the primary toxicity associated with an overdose of the muscle relaxer orphenadrine?
An overdose of orphenadrine can lead to antimuscarinic toxicity, seizures refractory to standard treatment, respiratory failure, and cardiac toxicity.
Dhaliwal, N., & Roberts, D. M. (2024). Clinical outcomes associated with orphenadrine deliberate self-poisoning: a retrospective poisons centre study. Clinical Toxicology, 62(3), 168–173. https://doi.org/10.1080/15563650.2024.2323678
Contributed by Sheila Goertemoeller, PharmD DABAT
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