Historical QOD 4/1/09: True or false? In contrast to poisoning with phenytoin or carbamazepine, nystagmus, dysarthria and ataxia are only rarely noted in association with valproic acid poisoning.
True. The clinical findings most commonly associated with valproic acid poisoning include: CNS depression, nausea, vomiting, diarrhea, hypothermia, fever, hypotension, tachycardia, miosis, agitation, hallucinations, tremors, myoclonus,seizures and in severe cases respiratory and multi-organ failure.
Lheureux P and Hantson P. 2009. Clinical Toxicology, 47(2): 101-111
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