Carbon monoxide poisoning occurs very rapidly in high concentrations. What toxin can cause the delayed release to prolonged carbon monoxide toxicity?
Methylene chloride can be found in paint strippers, aerosol paints, and metal cleaning solutions. Methylene chloride toxins may produce carbon monoxide through their metabolic degradation process, catalyzed by Cytochrome P450 CYP 2E1. Methylene chloride forms formyl chloride, which in turn releases carbon monoxide, leading to the delayed release of prolonged carbon monoxide toxicity.
Jaffe TA, Boyer EW, Erickson TB, Studley H, Hayes BD, Chai PR. Acute and delayed toxicity from co-ingestion of methylene chloride and methanol. Toxicol Commun.2019;3(1):79-84. doi:10.1080/24734306.2019.1685222
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