Question Of The Day

According to a recent report of severe arthroplastic cobalt toxicity, which two agents may be effective in briding a patient to surgical intervention? N-acetylcysteine and DMPS Pelclova D, Lach K. Efficacy of unithiol (2,3-dimercaptopropanesulfonate) and acetylcysteine in a patient with arthroplastic cobalt toxicity. Clin Toxicol…

Historical QOD 11/21/08: In the early 1980’s a number of young adults in northern California developed a dense parkinsonian syndrome following the IV use of what was thought by them to be synthetic heroin. Subsequent investigation determined this material to contain what chemical that has…

In 2023, Oregon encacted laws legalizing the manufacture and use of psilocybin products in licensed facilities for supervised sessions with facilitators. According to the statute, recent use of which single pharmaceutical precludes participation in a psilocybin session? A client who self-reports taking lithium in the…

In a recent case report of respiratory depression from metonitazine toxicity, what dose of naloxone was required for effective reversal? A single dose of 0.4 mg was effective in reversing depression. White A, Seah V, Brown J, McDonald C, Tran J, Roberts DM. Acute metonitazene…

In a recent study of the accuracy of mushroom identification applications, how reliably were poisonous mushrooms identified? In the cited study, mushroom identification applications identifeid poisonous mushrooms 30-44% of the time depending on the application used. Hodgson SE, McKenzie C, May TW, Greene SL. A…

Which of the following was associated with higher rates of hospital admission and serious adverse outcomes in a study on Kratom exposures to poison centers: single substance ingestions or multi-substance ingestions? Multiple-substance exposures were associated with greater odds of admission to a HCF (OR: 2.80;…

Historical QOD 11/20/08: Acute poisoning involving nutmeg primarily involves nausea, vomiting, and abdominal pain as well as a variety of CNS and cardiovascular effects. The genus and species of the nutmeg tree is Myristica fragrans.What are the toxicologically relevant components of nutmeg? Nutmeg contains 5-15%…

In a case report examining the potential mechanism for Kratom – related cardiac arrest, what was the proposed mechanism of cardiac arrest? Kratom use potentially leads to status epilepticus resulting in cardiac arrest. Hannah Wolfer, Roy Gerona & Adam Blumenberg (2020) Evidence of a potential…

What is the proposed mechanism by which tianeptine is thought to have high abuse potential? Tianeptine’s high potential for abuse is due to its strong affinity at the mu-opioid receptors and through increases in extracellular dopamine concentrations throughout cerebral tissue. William Rushton, Brian Whitworth, Julie…

In the most recent EXTRIP publication, at what concentration of ethylene glycol is Extracorporeal Treatment recommended in patients treated with fomepizole? EXTRIP recommends Extracorporeal Treatment in patients with ethylene glycol concentrations greater than 50 mmol/L Ghannoum M, Gosselin S, Hoffman RS, Lavergne V, Mégarbane B,…