Question of the Day – Friday, April 28, 2023
What is the duration of the analgesic effect of methadone compared to the withdrawal prevention effect? The duration of analgesia is 4-6 hours initially; with repeat dosing, 8-12 hours. The duration of withdrawal prevention is 30-60 hours Katzung K, Laes J, Weigand T. 2023 ACMT…
Question of the Day – Thursday, April 27, 2023
Historical QOD 12/02/08: What problem with measuring 1,3-propanediol by GC-MS requires clinicians to maintain a high level of suspicion for this toxicant? 1,3-propanediol is used as the internal standard used in GC-MS for measuring glycols. So, a person poisoned by 1,3-propanediol won’t have a corresponding…
Question of the Day – Wednesday, April 26, 2023
What adverse drug effect from trimethoprim-sulfamethoxazole has recently been associated with HLA-B*07:02 and HLA-C*07:02? All cases of respiratory failure in association with trimethoprim-sulfamethoxazole were heterozygous or homozygous for the above haplotype. Carmparison to control suggests that HLA-B*07:02 and HLA-C*07:02 are necessary for a patient to…
Question of the Day – Tuesday, April 25, 2023
What observations were made when Danish investigators analyzed data from acetaminophen overdoses before and after a public health initiative that limited the package size of acetaminophen products to a max of 10 grams? The authors identified a lower number of paracetamol poisonings, a decreased proportion…
Question of the Day – Monday, April 24, 2023
This blood biomarker may indicate recent cannabis smoking? Cannabigerol (CBG). Rague JM et al. The minor cannabinoid cannabigerol (CBG) is a highly specific blood biomarker of recent cannabis smoking. Clin Tox 2023 Published online 20 March 2023.
Question of the Day – Friday, April 21, 2023
Acute Exposure Guideline Levels are described as “level 1”, “level 2”, or “level 3”. What is the difference? AEGL “levels” are dictated by the severity of the toxic effects caused by the exposure. All levels are expressed as parts per million or milligrams per cubic…
Question of the Day – Thursday, April 20, 2023
Historical QOD 12/01/08: What compounds are used instead of ethylene glycol in ?non-toxic? anti-freeze? Are they potentially harmful? Antifreeze traditionally contains ethylene glycol, but some brands marketed as low toxicity or ?non-toxic? use 1,2-propanediol (aka propylene glycol) or 1,3-propanediol (aka trimethylene glycol or 1,3-dihydroxypropane). Although…
Question of the Day – Wednesday, April 19, 2023
What does AGEL stand for and what does it mean? Acute exposure guideline levels (AEGLs) describe the human health effects from once-in-a-lifetime, or rare, exposure to airborne chemicals. Used by emergency responders when dealing with chemical spills or other catastrophic exposures, AEGLs are set through…
Question of the Day – Monday, April 17, 2023
What neurotoxic findings have recently been observed in patients envenomated by the Southern Pacific rattlesnake (Crotalus helleri)? The authors of the cited reference therorize that small basic peptides found in Southern Pacific rattlesnakes in the Los Angesles region posesses excitatory, mytoxic, and beta neurotoxic…