Question Of The Day

Strong inhibition of the DJ-1 (Park7) protein by which chemical class of pesticides was found to potentially be involved in the development of Parkinson’s Disease? The thiocarbamates (e.g. mancozeb, maneb, propineb, thiram, triallat, zineb, ziram) were found to be major inhibitors of DJ-1. Because DJ-1…

In a recent study linking records from the American Community Survey to the National Death Index (2008 to 2019), what sociodemographic characteristic was found to increase the risk of drug overdose death? Olfson M et al. evaluated American Community Survey data and National Death Index…

What is cyclizine? Cyclizine is a Pipirazine H1 antagonist used for nausea and vomiting outside of the United States. It is available IV, IM, and oral. Jensen TL, Tejlbo Frost M, Dalhoff K, Studsgaard Petersen T. Repeated poisonings in Denmark – a nationwide study. Clin…

Historical QOD 12/17/08: What mineral, other than amphibole asbestos, has been causally linked to mesothelioma? Erionite. Erionite is a fibrous mineral found in zeolite stones used to build houses in the Cappadocia region of Turkey. Baris YI, Sahin AA, Ozesmi M, Kerse I, Ozen E,…

How commonly does serotonin syndrome occur with linezolid combined with antidepressants? Bai et al. studied older adults (>/= 66 y) in the ICES database in Ontario, Canada who received oral linezolid between 1 Oct 2014 and 1 Jan 2021. The authors looked for SS, altered…

Linezolid carries a warning for risk of serotonin syndrome when taken concomitantly with serotonergic antidepressants. What is the mechanism for this drug-drug interaction? Linezolid has some reversible inhibitory effect on monoamine oxidase (MAO). Bai AD, McKenna S, Wise H, Loeb M, Gill SS. Association of…

Chronic, supratherapeutic use of Trimethoprim/Sulfamethoxazole is associated with which adverse effect? “Use of BACTRIM at high doses and/or for extended periods of time may cause bone marrow depression manifested as thrombocytopenia, leukopenia and/or megaloblastic anemia. If signs of bone marrow depression occur, the patient should…

Treatment of livestock with which pharmaceutical drug resulted in near extinction of vulture species in SE Asia? Treatment of livestock with diclofenac resulted in the near extinction of vulture species secondary to renal failure in SE Asia Naidoo V, Wolter K, Cromarty D, Diekmann M,…

Historical QOD 12/12/08: What effect is associated with Coprinus atramentarius ingestion? Disulfram effect. The Coprinus atramentarius mushroom contains the toxin coprine. Coprine and its major metabolite both inhibit aldehyde dehydrogenase. If the Coprinus atramentarius mushroom is ingested with ethanol, the accumulation of acetaldehyde will cause…

Which chemotherapeutic agent was this patient treated with prior the development of the depicted dermatitis? The above image depicting a flagellate dermatitis was obtained soon after treatment with bleomycin for ovarian germ cell tumor. Verma P, Rajaram S, Heda A, Sundriyal D, Tiwari P, Sahoo…