Question Of The Day

In calcium channel blocker overdose, is intralipid recommended according to 2023 American Heart Association Focused Update? In this consensus guideline routine use of intralipid is not recommended. The guidelines state the following evidence “A large retrospective study did not find a benefit from ILE therapy…

In a study conducted by a Veterans Affairs ED, pharmacists screened patients over 70 years of age for potentially inappropriate medication (PIM) prescriptions and sent a message to the patient’s primary care provider with recommendations for changing the prescription. What percent of patients had a…

Historical QOD 3/9/2009: What are the laboratory indicators of arsenic-induced nephrotoxicity? Urinary blood, and increased urinary protein, ketones, and bilirubin (Internat J Toxicol, 2008 5(2))

The production of what metal has led to pulmonary fibrosis and progressive encephalopathy among potroom workers, also known as “potroom asthma” and “potroom palsy”? Aluminum. Potroom workers exposed to high concentrations of aluminum dust mixed with mineral-oil based lubricants developed pulmonary fibrosis or “aluminosis”. Some…

The American Geriatric Society published its most recent Beers Criteria in 2023. What are Beers Criteria and in what circumstances can these criteria be applied? The AGS’ Beers Criteria aims to identify potentially inappropriate medication (PIM) use in older adults. The criteria are intended to…

What is the toxin contained in this plant (Anamirta cocculus) and its mechanism of toxicity? Anamirta cocculus, commonly known as the fish-berry, contains picrotoxin which is a GABA-A receptor antagonist. It noncompetitively binds the picrotoxin binding site of the GABA-A receptor, closing the chloride ion…

Among the following anticonvulsant agents, which would be expected to exhibit the most worrisome cardiotoxicity in an acute overdose? A) phenytoin B) cannabidiol C) levitriacetam D) carbemazepine E) perampanel D) Carbamazepine. Carbamazepine is active at voltage gated sodium channels, and shares structural similarities to the…

Historical QOD 3/6/2009: True or False:  All of the fatalities from the 1995 sarin attack on the Tokyo subway system resulted from exposure to liquid sarin rather than sarin vapor and occurred within 48 hours of the exposure. False. One 51-year-old man who inhaled sarin…

Selenium is an element essential to life, and found in trace amounts in humans obtained from dietary sources. In certain forms, however, it is an immediate threat to life. Which form of selenium occurs as a gas with a characteristic horseradish or rotten egg scent,…

Among patients treated with immune checkpoint inhibitors, which of the following subtypes of either PD-1 (programmed cell death protein 1) or CTLA-4 (cytotoxic T lymphocyte-associated protein 4) is more likely to lead to toxicity including pneumonitis? PD-1 agents including nivolumab and pembrolizumab are more likely…