Administrator Clintox - One

What already FDA approved compound maybe a potential antidote for hepatotoxicity from Amanita phalloides? According to the cited reference, indocyanine green has been shown in vitro and in mice models to decrease update of Alpha amanitin into cells and decrease liver damage. Wang, B., Wan,…

Are neonates at risk for neonatal abstinence syndrome after in utero exposure to tianeptine? According to the cited case report, a French mother reported chronic use of >650 mg daily of tianeptine prior to giving birth to a full term neonate who developed neonatal abstinence…

The patient in the picture below suffered exposure to which toxic compound frequently used in solar power panel manufacturing? Tellurium Blackadder ES, Manderson WG. Occupational absorption of tellurium: a report of two cases. Br J Ind Med. 1975 Feb;32(1):59-61. doi: 10.1136/oem.32.1.59. PMID: 123755; PMCID: PMC1008023….

What medication can be used to reverse some effects of tianeptine? Naloxone. Tianeptine is a full agonist of mu-opioid receptors. Therefore, naloxone has a theoretical and some real-world experience with reversal of tianeptine overdose. Dempsey SK, Poklis JL, Sweat K, Cumpston K, Wolf CE. Acute…

Historical QOD 3/31/09:True or False: Fluoroquinolones as a class are some of the most potent photosensitizers causing photosensitivity rashes. True. While tetracycline-class antibiotics are commonly associated with this phenomenon, they are at most weak photosensitizers, with the exception of doxycycline, which is much more potent….

What receptors does tianeptine interact with? According to the cited reference, tianeptine “was originally classified as a tricyclic antidepressant, but because it did not inhibit monoamine reuptake, this description is inaccurate… [Tianeptine is] more accurately described as a glutamatergic modulator and a µ-opioid receptor and…

What toxin(s) in what edible substance may have caused Ludwig van Beethoven’s deafness? Lead contaminated wine. Many historians and toxicologists have speculated on this problem. Many conditions may have contributed to Beethoven’s deafness. However, temporal bone analysis showed elevated levels of lead. Beethoven’s wine consumption…

In patients presenting with ethylene glycol toxicity, administration of pyridoxine and thiamine can shunt metabolism away from the formation of which toxic metabolite? Glyoxylic acid Gallagher N, Edwards FJ. The diagnosis and management of toxic alcohol poisoning in the emergency department: a review article. Adv…

What are the characteristics of pit vipers that distinguish them from non-venomous snakes? According to the cited source, these snakes have “two pits (with heat-sensitive organs that assist these poor-visioned reptiles to localize their prey) are located on each side of the head, between the…

Historical QOD 3/30/09: Describe the mechanim of lead-induced anemia. Lead interferes with a variety of heme biosynthetic enzymes, including delta-aminolevulinc acid (acting to synthesize porphobilinogen), and ferrochelatase (used to incorporate iron into protoporphyrin). In the latter case, zinc is inserted in the place of iron,…