Administrator Clintox - One

An 11-year-old boy was taken to the emergency room by his parents due to acute cyanosis, respiratory distress and altered mental status. The parents stated that the child had been playing in a nearby mechanic shop and had possibly ingested some unknown substance. Physical Examination:…

Historical QOD 4/13/09: What are the neurotoxic effects that have occasionally been reported in the setting of industrial exposure to cobalt? The primary neurotoxic effects reportedly associated with occupational exposure to cobalt include optic atrophy, nerve deafness and limb paresthesias. Rizzetti MC, et al. The…

In a study that compared simulation-based training to a traditional lecture-based format, four toxicology topics were taught to both groups in four 20-min sessions. Which group had better improvement immediately after the sessions and which group had better retention at 3 months? The group taught…

In a 2018 survey of ACGME approved EM residencies (in which 107/164 responded), how many mandated a toxicology rotation that was more than one hour away from the home institution? Nine programs required a rotation between 1-12 hours away from the home institution Darracq MA,…

What is the SILENT syndrome and what are its features? The syndrome of irreversible lithium-effectuated neurotoxicity, or SILENT syndrome, is diagnosed when a patient has persistent neurological changes that persist at least 2 months after lithium discontinuation. Elevated lithium concentrations are not necessarily required to…

What is the sodium dithionite test? The sodium dithionite test Is a urine test rarely performed in the clinical setting to differentiate diquat poisoning from other pesticides. It is performed by mixing 1 gram of sodium dithionite and 1 gram of sodium bicarbonate and with…

Historical QOD 4/10/09: Dopamine agonists used in the treatment of Parkinsons Disease have been reported to result in a variety of compulsive behaviors including pathologic gambling and hypersexualtiy. What other problematic compulsive behaviors have been associated with dopamine agonist therapy? Compulsive eating, excessive shopping, excessive…

What are the intrathecal-pump-related issues that could cause baclofen withdrawal? According to the cited reference, intrathecal pump-related reasons for baclofen withdrawal could include catheter dislodgement, kinking, or migration; pump device malfunction; and reservoir under filling. Reservoir underfilling is when a reservoir is missed during the…

Which class of antibiotics has been shown to reduce serum levels of valproic acid? carbapenems Khobrani MA, Dudley SW, Huckleberry YC, Kopp BJ, Biggs AD, French RNE, Shirazi FM, Erstad BL. Intentional use of carbapenem antibiotics for valproic acid toxicity: A case report. J Clin…