Administrator Clintox - One

Historical QOD 4/21/2009: What is the relative incorporation rate (ICR) for cocaine versus THC into human hair? THC and (especially) its main metabolite 11-nor-_9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) have very low incorporation rates (ICR) into hair, with a 3600-fold difference between the ICR of cocaine and that…

HAPPY NACCT 2024! AACT QOD Committee thanks the following individuals along with their teams for their tremendous contributions to QOD. Writing these questions takes time and commitment to the Academy and we are grateful for your dedication and contribution to our specialty. Hannah Hays &…

A cross-sectional study of patients admitted with tramadol poisoning conducted at a tertiary referral hospital in Tehran, Iran compared genetic polymorphisms of mu opioid receptors and adverse effects of tramadol overdose. What was the relationship between mu1 A118G genotype and adverse effects of tramadol? This…

A retrospective cohort study consisting of patients with delirium secondary to second generation antipsychotics reported to a single poison center was conducted. What percentage had a positive response to physostigmine and what percent had an adverse reaction? A positive response was noted in 82.8% [95…

According to the National Cancer Institute’s Health Information National Trends Survey (HINTS) 5 Cycle 4 (a nationally representative mailed survey), what percentage of adults were aware of the increased risk of cancer with alcohol use? Awareness of an increased cancer risk was lowest for wine…

Historical QOD 4/16/09: Aside from being bitten and seriously envenomed what is another potentially fatal occupational risk for professional (or non-professional for that matter) snake handlers? Specific IgE sensitization to snake venoms is a potentially significant and serious hazard for snake handlers who sustain repeated…

A study was performed on data from the US Department of Veterans Affairs on 7.9 million persons without preexisting liver or biliary disease who initiated a suspected hepatotoxic medication in the outpatient setting. Which drugs were considered responsible for more than 10 epidosodes of acute…

What is the mechanism that leads to symptoms from inhalation anthrax exposure? According to the cited source, “inhalation anthrax results from spore update in the alveoli by pulmonary macrophages, followed by bacterial germination and toxin production in the mediastinal lymph nodes, leading to hemorrhagic lymphadenitis,…

What EEG findings distinguish SESA syndrome (subacute encephalopathy with seizures in alcoholics) from chronic alcoholism? Focal slowing, spiking, and LPDs (lateralized periodic discharges) Fernández-Torre JL, Kaplan PW. Subacute Encephalopathy With Seizures in Alcoholics Syndrome: A Subtype of Nonconvulsive Status Epilepticus. Epilepsy Curr. 2019 Mar-Apr;19(2):77-82. doi:…