Question of the Day – Friday, May 26, 2023
A recent retrospective study of calcium channel blocker poisoned patients found that patients with amlodipine poisoning experienced more vasodilation when treated with high-dose insulin (HDI) than those poisoned by of non-dihydropyridines. What is the proposed mechanism? HDI acts as a vasodilator via enhancement of endothelial…
Question of the Day – Thursday, May 25, 2023
Historical QOD 12/05/08: Abuse of 1-benzylpiperazine (BZP), 1-(3-trifluoromethylphenyl)piperazine (3-TFMPP), and 1-(3-chlorophenyl)piperazine (3-CPP) is becoming increasingly popular in what setting? These compounds have become popular as dugs of abuse at a variety of dance clubs where they may be marketed as legal alternatives to MDMA. Elliott…
Question of the Day – Wednesday, May 24, 2023
Should cholinesterase inhibitors, such as rivastigmine and physostigmine be withheld in patients with diabetes mellitus? The package insert for physostigmine does list diabetes as a contraindication because it can theoretically stimulate pancreatic M3 receptors and change insulin requirements. However, in the acute management of anticholinergic…
Question of the Day – Tuesday, May 23, 2023
What is “the Horowitz Dodecad,” and what does it indicate? The Horowitz Dodecad: Dry mouth, Diplopia, Dilated pupils, Droopy eyes (ptosis), Droopy face, Diminished gag reflex, Dysphagia (difficulty swallowing), Dysarthria (difficulty articulating speech), Dysphonia (difficulty phonating/whispered speech), Difficulty lifting head, Descending paralysis, Diaphragmatic paralysis. All…
Question of the Day – Monday, May 22, 2023
What is the International Platinum Group Metals Association (IPA)? The International Platinum Group Metals Association (IPA) is a non-profit association that represents the worldwide leading mining, production and fabrication companies in the global platinum group metals (PGMs) industry, comprising platinum, palladium, iridium, rhodium, osmium and…
Question of the Day – Friday, May 19, 2023
In a case report of two patients who reportedly developed pulmonary edema after naloxone administration, what was the authors conclusions regarding the potential relationship/cause of naloxone and pulmonary edema? Authors concluded the effect appears to be dependent on the dose of naloxone administered (specifically higher…
Question of the Day – Thursday, May 18, 2023
Historical QOD 12/04/08: Abuse of what substance can lead to positive trichloroethanol in the absence of exposure to chloral hydrate? Sniffing or inhaling contact cement. Some contact cement products may contain trichloroethylene which is metabolized to trichloroethanol and may cause positive trichloroethanol levels at autopsy….
Question of the Day – Wednesday, May 17, 2023
Which of the following statements is FALSE according to the article ‘Do heroin overdose patients require observation after receiving naloxone? a) An observation period of one hour is sufficient for most patients with a GCS of 15, normal vital signs, and ambulating per usual who…
Question of the Day – Tuesday, May 16, 2023
In a 2019 pilot study on intranasal nalmefene as a rescue medication for synthetic opioid overdose, what dose of nalmefene with dodecyl maltoside (DDM) had a lower time to maximum concentration than intranasal naloxone? 3 mg of nalmefene with DDM Krieter P, Gyaw S, Crystal…
Question of the Day – Monday, May 15, 2023
What are some common side effects of high dose methotrexate therapy? After taking HD-MTX, 60% develop reversible hepatitis and 25% develop hyperbilirubinemia. More than 25% of patients who receive MTX treatment have coughing, wheezing, breathlessness, or other respiratory problems. The likelihood of nephrotoxicity in lymphoma…