Administrator Clintox - One

Historical QOD 4/23/09: What is NHANES? NHANES is the “National Health and Nutrition Examination Survey” and is a program of studies designed to assess the health and nutritional status of adults and children in the United States. The survey is unique in that it combines…

In the recent study of benzodiazepine poisoning cases reported to U.S. poison centers, what was the association between the co-use of prescription opioids and the likelihood of major medical effects or death in intentional misuse cases? The co-use of prescription opioids was associated with a…

In a 2019 case report describing the possibility of tolerance and dependence in chronic dextromethorphan hydrobromide abuse, what was the measured variable? Serum chloride concentration Olives TD, Boley SP, LeRoy JM, Stellpflug SJ. Ten Years of Robotripping: Evidence of Tolerance to Dextromethorphan Hydrobromide in a…

Patients using methadone to treat opioid use disorder were divided into two groups. One group received acupuncture and the other received sham acupuncture. What where the differences between groups in regarding reduction of methadone dose and opioid cravings? More patients who received acupuncture reduced their…

Which of the GLP-1RAs discussed in the article by Gaw, et al had a significantly increased rate of adverse events? Semaglutide (Wegovy) Gaw CE, Hays HL, Kemp CA, et al. Glucagon-Like Peptide-1 Receptor Agonist Cases Reported to United States Poison Centers, 2017-2022. J Med Toxicol….

Historical QOD 4/22/09: What are the MRI findings associated with “chasing the dragon” use of heroin? The most distinguishing MRI feature of chasing toxicity is the pattern of diffuse increased T2W signal within the white matter tracts of the cerebellum, brainstem and supratentorial brain including…

Through what mechanism is vasoplegia theorized to occur in amlodipine overdose patients receiving high dose insulin infusions? Synergistic induction of eNOS by both amlodipine and HDI therapy Cole JB, Lee SC, Prekker ME, et al. Vasodilation in patients with calcium channel blocker poisoning treated with…

The number of adolescent patients presenting to a single health system from 2014-2022 with opiate-related complaints increased. Over the same time period, positivity rates of urine drug screens (UDS) fell (from 2014 to 2019 were 82% ± 6% and from 2020 to 2022 were 5%…

446 cases of morel mushroom poisoning were reported in France between 2010-2020. What organ systems were most often reported to be affected? Most patients developed gastrointestinal (83.6%) and neuro-logical symptoms (53.3%), with both in 38.5% of cases. Vodovar, D., Le Visage, L., Caré, W., Langrand,…

In a European study of patients comparing self-report of cannabis exposures vs synthetic cannabinoid exposures, which group was more likely to experience drowsiness, coma, agitation, seizures and bradycardia? Synthetic canna-binoid receptor agonist presentations had statistically significantly higher rates of drowsiness, coma, agitation, seizures and bradycardia…