Administrator Clintox - One

Historical QOD 1/21/2009: True or False: Patients with hyperthyroidism are more prone to develop digoxin toxicity? False. Patients with HYPOthyroidism are reportedly more susceptible to the effects of digoxin. El-Salawy SM. Lowenthal DT. Ippagunta S. Bhinder F. Clinical Pharmacology and Physiology Conference: digoxin toxicity in…

How does the public’s identification of copperhead snakes and cottonmouth snakes compare to that of medical toxicologist who were provided pictures of the snake? A study in Mississippi showed that callers to the local poison control center in their cohort had an overall accuracy in…

In a case cluster describing patients experiencing the disulfiram reaction after ingestion of Coprinus atramentaria up to how many hours after mushroom ingestion is the disulfiram effect observed for if ethanol is also ingested? 72 hours Reynolds WA and Lowe FH. Mushrooms and a Toxic…

In a single-center retrospective observational study examining the risk of adverse events associated with Disulfiram-ethanol reaction (DER) and the use of fomepizole in patients, DER may be responsible for life-threatening vasodilatation requiring vasopressors and accompanied by marked ECG alterations. What was the cause of this…

In a 2023 retrospective case control study, what was the incidence of disulfiram-like reactions in patients who received metronidazole and ethanol concurrently as compared to control group (ethanol only)? There was no increase in incidence of disulfiram-like reaction in metronidazole group. Feldman R, Jaszczenski R….

Historical QOD 1/20/2009:  Which chemical is produced as a metabolite of both chloral hydrate and trichloroethylene? Both of these chemicals are metabolized to trichloroethanol. This may result in inaccurately attributing trichloroethylene overdose to chloral hydrate. Tricholorethylene, while commonly used as a degreasing solution, can also…

Identify this snake.  Where does it call home and what toxicity is associated with it? This is a bump-nosed pit viper (Hypnale Hypnale).  It is native to Sri Lanka and India.  It is responsible for the majority of venemous snake bites in Sri Lanka and…

An MRI with T2/FLAIR hyperintensities in a symmetric, bilateral periventricular white matter distribution with T2-weighted hypointensities involving the basal ganglia and/or thalami is most consistent with the leukoencephalopathy associated with use of which of the following agents? A.Methyl bromide B. Toluene C. Methotrexate D. Carbon…

Intranasal cocaine-induced midline destructive lesions are described to be difficult to distinguish from what small vessel vasculitis? Granulomatosis with polyangiitis (GPA) (formerly Wegener’s granulomatosis). Both conditions exhibit similar features when limited to destructive nasal lesions, and have positive anti-neutrophil cytoplasmic antibodies [1]. However, human neutrophil…

Yew trees (genus Taxus) contain cardiotoxic taxine alkaloids. What are the differences among Taxus baccata (English yew), T. canadensis (Canadian yew), and T. brevifolia (Pacific yew)? 1.baccata (English yew) and T. canadensis (Canadian yew) contain higher concentrations of taxine A and taxine B. Dela Cruz…