Administrator Clintox - One

According to a recently published case report about the side effects of tirzepatide, which of the following is true regarding dual glucagon-like peptide-1 receptor and glucose-dependent insulinotropic polypeptide agonists? A. greater doses are associated with more frequent gastrointestinal side effect B. hypoglycemia is a common…

Historical QOD 3/3/2009: What is the primary cytochrome P450 enzyme responsible for metabolizing nicotine? CYP2A6, and variability in the activity of this enzyme contributes to susceptibility to tobacco dependence, response to therapy, and risk for lung cancer. Benowitz NL. Pharmacology of nicotine: addiction, smoking-induced disease,…

In a retrospective review of data from the National Poison Data System, the safety of physostigmine in pediatric patients was assessed. What was the median age of the patients who received physostigmine? The median age of the groups that received physostigmine was 15 years. Huber…

What fruit derives its scientific name from Captain William Bligh, who took the fruit from Jamaica to the Royal Botanic Gardens in England? Ackee fruit (Blighia sapida) https://www.smithsonianmag.com/travel/captain-blighs-cursed-breadfruit-41433018/ Contributed by Willie Eggleston

The American Geriatric Society published its most recent Beers Criteria in 2023. What are Beers Criteria and in what circumstances can these criteria be applied? The AGS’ Beers Criteria identify potentially inappropriate medication (PIM) use in older adults. The criteria are intended to apply to…

In a retrospective, cross-sectional study performed in an urban hospital in Minneapolis, MN, what was the greatest risk factor for patients having physical restraints applied? Drug and alcohol intoxication was associated with the highest odds ratio of having physical restraints (adjusted odds ratio [aOR] 8.29;…

Historical QOD 3/2/2009: What findings predominate in renal biopsies of patients with lithium toxicity? Chronic tubulointerstitial nephropathy (CTIN), cortical and medullary tubular cysts and dilatation, and focal segmental and global glomerulosclerosis.  Image: Severe lithium-associated chronic tubulointerstitial nephropathy (CTIN) with diffuse interstitial fibrosis and tubular atrophy…

What is the mechanism for colchicine induced cardiotoxicity? Although widely used in gout and pericarditis, colchicine can cause cardiotoxicity when taken in overdose due to its narrow therapeutic window. Though not well understood, high levels of colchicine may induce microtubule depolymerization, thus inhibiting contractility and…

In a small retrospective case control study of patients with delusions of parasitosis, exposure to what medications was associated with the delusions? Patients with delusions of parasitosis were more commonly exposed to attention deficit disorder medications, selective serotonin reuptake inhibitors, opioids, and gabapentin, along with…