Administrator Clintox - One

Historical QOD 3/17/2009: True or False:  In building fires, the vertical and horizontal dispersion of toxic gases has been found to be relatively uniform. False.  Concentrations of toxic gasses in fires are indeed relatively constant at a given height over surprisingly long distances from the…

Correction to QOD 4/30/24: The original question should have read the following- In a secondary analysis examining the association of QRS prolongation with serious adverse effects:  1) Amongst xeniobiotics studied, which of the following adverse effects was the negative predictive value the worst? A. seizures…

To what familiar drug is orphenadrine most closely related? Diphenhydramine. Orphenadrine is ortho-methyl diphenhydramine (adding one methyl group to one of the benzene rings Dhaliwal N, Roberts DM. Clinical outcomes associated with orphenadrine deliberate self-poisoning: a retrospective poisons centre study. Clin Toxicol 2024 (online ahead…

What are the typical clinical findings after orphenadrine overdose? In a review of 46 patients with orphenadrine overdose, most patients had antimuscarinic symptoms. At lower doses, patients often had drowsiness (22) and sinus tachycardia (15). At progressively higher doses, patients had delirium (13) and urinary…

Botulism immune globulin (BIG) contains neutralizing antibodies towards what antigenic variants of botulinum toxins? Each 50 mg of BIG contains at least 15 IU of neutralizing antibodies directed against toxin type A and at least 4 IU of neutralizing antibodies directed against toxin type B…

Ingestion of Hawthorne root can cause what false-positive laboratory test? False positive serum digoxin concentration. Hawthorne root (Crategus mexicana) with the Spanish common name “raiz de tejocote”, contains flavonoids that appear to cross-react with the digoxin assay. Two case reports found apparent digoxin concentrations of…

Historical QOD 3/13/2009: True or False:  The only currently used mouthwash ingredient to which death has been attributed is ethanol. False. A death from ingestion of three liters of an essential-oil-containing mouthwash was attributed to the terpenes that were the active ingredients in the mouthwash….

True or False. According to a recent study, patients with drug related out-of-hospital cardiac arrests are less likely than those with presumed cardiac causes of arrest to receive bystander resuscitation but are more likely to survive. TRUE Orkin AM, Zhan C, Buick JE, et al….

In a secondary analysis examining the association of QRS complex duration prolongation with serious adverse effects, the positive predictive value was highest for which adverse effect amongst the xenobiotics studied? Seizures Simon M, Kaplan S, Muschler K, Hoyte C, Brent J. The role of QRS…

According to an article in 2024, above what amount of caffeine ingestion can cause fatal arrhythmias, such as ventricular fibrillation? 6.0 g of caffeine Mitsui D, Kamijo Y, Yoshino T, Hanazawa T, Yoshizawa T, Iwase F. Severe caffeine poisoning treated with intermittent hemodialysis under circulatory…