Administrator Clintox - One

Question:  C. diphtheriae is an aerobic gram-positive bacillus. Toxin production (toxigenicity) occurs only when the bacillus is itself infected (lysogenized) by a specific virus (bacteriophage) carrying the genetic information for the toxin (tox gene). Only toxigenic strains can cause severe disease. What is the pathogenesis of toxigenic diphtheria?

Question: The triad of acute kidney injury, microangiopathic hemolytic anemia, and thrombocytopenia characterize the hemolytic uremic syndrome (HUS). This typically occurs following a GI infection with which toxin producing pathogen?

Question: Stevens-Johnson’s syndrome and toxic epidermal necrolysis are potentially fatal mucocutaneous diseases that in some cases may be due to a variety of drugs. Which drugs are most commonly implicated as etiologic agents in pediatric patients suffering from these diseases?

Question: Tick paralysis is a rare condition that can lead to significant morbidity and death is undiagnosed. Most cases of tick paralysis have been reported from Australia or North America including in the United States—the Pacific Northwest, the Rocky Mountain states, and the Southeast— and southwestern Canada. In North American which species of tick has been implicated as the most common vector causing tick paralysis?

Question: Which drug is the first radioprotectant approved by the U.S. FDA?

Question:  Which drug, recommended based on its anti-inflammatory effects in treating the serositis associated with familial Mediterranean fever, has been recommended for the treatment of recurrent pericarditis?

Which oral chelating agent has been reported to cause transient increases in plasma ALT activity in some patients as well as rare instances of mucocutaneous skin reactions?