Administrator Clintox - One

Cases reported to the Toxicology Investigators Consortium between January 1, 2010, and December 31, 2022 were assessed to determine the assiciation with prolonged QRS (>120 ms) and development of seizure, metabolic acidosis, or ventricular dysrhythmia after intoxication with several substances. In patients with nortriptyline ingestion,…

Part of the Advanced Roadside Impaired Driving Enforcement and Drug Recognition Evaluator assessment (from the International Association of Chiefs of Police) for cannabis intoxication includes looking for eyelid tremor during the modified Romberg test. In a cohort study of cannabis users vs non-users, was eyelid…

Comparing the new-Poisoning Mortality Score and the Modified Early Warning Score for predicting mortality in patients with acute toxicity, which system was more accurate in a large Korean study? The new- Poisoning Mortality Score was more senstive (0.863 vs 0.667), specific (0.912 vs 0.817) and…

In a study of pediatric Han Chinese patients, which risk factor was associated with development of valproate toxicity (liver injury): age, sex, dose of valproate, or valproate concentration? Male patients had a higher percentage of liver injury (58.9%) compared to female patients (41.1%). Male patients’…

Historical QOD 3/20/09: What are three antiepileptic medications that have been reported to be causally associated with metabolic acidosis? Acetazolamide, zonisamide, and topiramate (Neurology, 2004 Nov 23, 63(10 Suppl 4):S24-S29)

In a retrospective review of patients treated with either oral or transdermal rivastigmine, which group required more additional doses of sedation to control antimuscarinic induced delirium? The group receiving transdermal rivastigmine required more doses of additional sedation compared to oral. Patients receiving the transdermal patch…

In a rodent study, liraglutide (flucagon-like peptide-1 receptor agonist) reduced self administration of what substance of abuse? Liraglutide reduced both cue-induced heroin seeking and drug-induced reinstatement of heroin seeking behaviors in rats. Evans B, Stoltzfus B, Acharya N, Nyland JE, Arnold AC, Freet CS, Bunce…

In a retrospective descriptive cohort study published in 2018 that evaluated the efficacy of naloxone in the reversal of clonidine toxicity in pediatric patients, what was the recommended naloxone dose and route? Naloxone 10 mg IV push Seger DL, Loden JK. Naloxone reversal of clonidine…

In the case report presented on ACEI toxicity what is the proposed mechanism of action of naloxone’s ability to reverse hypotension. Naloxone promotes the effect of enkephalinase, an enzyme responsible for endogenous opioid degradation (ie beta-endoprhin). Degradation of endogenous opioids inhibit angiotensin II which inhibits…