Question of the Day – Friday June 19, 2020
This vital sign abnormality was present in nearly 60% of patients with bupropion overdose? Offerman et al. report 437 patients with bupropion overdose and tachycardia was present in 56.5% of patients and 50.6% of patients had sustained tachycardia. Among patients with tachycardia on arrival,…
Question of the Day – Thursday June 18, 2020
There has been much discussion currently about the use of hydroxychloroquine in the management of SARS-COV-2 infection. What was the main cardiac toxicity seen in a subset of patients treated with hydroxychloroquine and azithromycin? In 84 patients treated with hydroxychloroquine and azithromycin, 30% of…
Question of the Day – Wednesday June 17, 2020
What is a new dietary ingredient (NDI)? What is aegeline? Per the 1994 Dietary Supplement and Health Education Act (DSHEA) and amendments since a NDI is any dietary ingredient not marketed in the US before 15 Oct. 1994. Conversely, any product marketed as a…
Question of the Day – Tuesday June 16, 2020
In 2018, there was an outbreak of synthetic cannabinoid-associated coagulopathy due to contamination of synthetic cannabinoids with broudifacoum, difenacoum and bromodialone. A recent study evaluated blood samples of 32 patients treated for bleeding disorders to this outbreak. What did this study find in regards to…
Question of the Day – Monday June 15, 2020
In a recent population based cohort study from Canada, there was a 75% increase in ED visits and near doubling of hospitalizations from 2010-2015 due to intentional overdose in youth. What were the most common substances involved in the overdoses? The most common substances…
Question of the Day – Friday June 12, 2020
Suicide is the second leading cause of death among adolescents. What is the risk of a nonfatal suicide attempt within one year? A nonfatal suicide attempt is a strong risk factor for completed suicide. There is a 32 fold increase in the risk of…
Question of the Day – Thursday June 11, 2020
What is the dermatological abnormality associated with chronic abuse of nitrous oxide? According to the cited reference, “The distribution and shade of pigmentation varied from patient to patient, but the most typical distribution is on the hands and feet, especially in the interphalangeal joint…
Question of the Day – Wednesday June 10, 2020
Genetic polymorphisms of which hepatic enzyme may influence the observed variable toxification of acrylonitrile? According to the cited reference, acute toxicity of acrylonitrile is dependent on its toxification to cyanide by CYP2E1. Significant variation in metabolic formation of cyanide has been observed in humans…
Question of the Day – Tuesday June 9, 2020
At a dose of 4 mg oral cyproheptadine TID, what percentage of CNS 5-HT receptors are blocked? According to the cited reference, at 4 mg TID, cyproheptadine blocks 85% of 5-HT receptors. At a dose of 6 mg TID, an estimated 95% of receptors…
Question of the Day – Monday June 8, 2020
A recent review outline the adverse events associated with single agent diphenhydramine exposure in children under 12 years of age. What was the frequency of associated seizures? The cited reference reports seizure in 5.5% of 2023 non fatal single ingredient exposures 2008-2015. (Palmer Rp…