Administrator Clintox - One

In a recent review, what was the incidence of Torsades des Pointes (TdP) in patients receiving droperidol?   Cole JB et al. performed a retrospective, observational cohort study from 1997-2001 in patients receiving parenteral droperidol for any indication. They found the incidence of TdP in…

Concentrations of hydrogen sulfide of greater than 500 ppm are expected to cause what clinical effects?   Coma, cardiovascular collapse and pulmonary edema occur with hydrogen sulfide concentrations greater than 500 ppm. The classic rotten egg odor is identifiable at concentrations as low as 0.02…

What were the most frequent reasons for medical evaluation in patients living in Martinique exposed to toxic gases of decompossing sargassum seaweed.   In a recent observational study performed in 2018 on the island of Martinique, patients most frequently reported neurologic, digestive and respiratory complaints….

In a recent retrospective review of ciguatera poisoning reported to the French Poison Control Centers, 91% of patients with ciguatera poisoning after consuming fish from the Atlantic Ocean had nausea, vomiting, diarrhea and abdominal pain as their first symptoms. This was vastly different if the…

Increased occupational exposure to styrene increases the concentration of this metabolite found in the urine?   A recent study in 53 plastic injection workers by Mohamadyan M et al. revealed that increased occupational exposure to styrene increased mandelic acid concentrations in the urine. Mohamadyan M…

The spur winged goose holds this toxin within its tissue?   The spur winged goose has a diet that includes ingestion of blister beetles. Cantharidin is held within the tissue of the fowl and can result in poisoning if ingested. Wikipedia. https://en.wikipedia.org/wiki/Spur-winged_goose. Accessed 24 June 2020

A recent study suggests that B-oxidation inhibition may play a role in initiation of hepatotoxicity after this commonly used xenobiotic?   Ganetsky M et al. performed a metabolomic analysis of acetaminophen induced subclinical liver injury to attempt to determine the role of 2E1 inhibition on…

“ZaZa” and “Tianna Red” are common names for this substance that has recently increased in use in the US?   Tianeptine is an antidepressant approved in some European countries with the trade names of Coaxil or Stablon. Over the past several years, tianeptine misuse and…

This laboratory finding was associated with deficits in episodic memory dysfunction in patients with acute organophosphate poisoning?   Complete RBC-AChE inhibition, compared to partial inhibition, was associated with deficits in episodic memory in patients that had acute organophosphate poisoning. These patients had poorer episodic memory…

This mitochondrial uncoupler recently was shown to reverse obesity and insulin resistance in mice.   BAM15 is a mitochondrial uncoupler, structurally unrelated to dinitrophenol, and in a recent mouse model was shown to be orally bioavailable and decreased body fat mass. In this model and…