Administrator Clintox - One

What is the cost impact on employers for patients with opioid use disorder treated with medication assisted therapy?   In a recent analysis of 17 million US workers using a commercial insurance claims database, Henke R et al. found that excess health care costs for…

What is the incidence of mortality following emergency department visits for nonfatal opioid overdose?   A cohort study including over 6,000 patients in Ontario, Canada found 5.3% died within one year and 1.9% died of opioid-related causes. Predictors of mortality included male sex, opioid agonist…

A 72 year old female is being treated for refractory acute promyelocytic anemia and is on day 16 of her chemotherapy regimen. On day 17, she collapsed and was found to be in torsades de pointes. What chemotherapeutic agent is the culprit?   Arsenic trioxide….

This chemical is the newest synthetic opioid to emerge on the illicit drug markets. In vitro data suggests that it has similar potency as fentanyl. It has appeared in both the US and Europe.   NPS Discovery reported that Brorphine has recently been identified in…

What is the overall survival of poisoned patients supported with ECMO?   Cole JB et al. recently reported results of their recent retrospective cohort study of NPDS data from 2000 through 2018 of poisoned patients supported with ECMO. In this cohort, there was a 70%…

What is Lhermitte’s sign, and what toxin induced clinical syndrome is it associated with?   Lhermitte’s sign is a clinical finding associated with flexion of the head resulting in a shower of parasthesia sensation through the upper and lower extremities. It is typically associated with…

What is Rossolimo’s sign, and chronic abuse of which drug is it associated with?   Rossolimo’s sign is a physical examination finding where percussion of the tips of the toes results in exaggerated flexion of the toes. It has been reported in association with nitrous…

In a simulated dialytic removal model, infusion of this drug resulted in the reduction of hemodialysis time to reach therapeutic concentration of carbamazepine from 265 to 220 minutes.   Maheshwari V et al. describes an innovative way to infuse a competitor drug into the extracorporeal…

In a recent prospective, cohort study of ED patients with drug overdose in a 5 year time frame, first-line push dose of this vasopressor was associated with higher in-hospital mortality?   According to Clifford C et al., patients who received push-dose phenlyephrine had a significantly…