Administrator Clintox - One

In a porcine model of acute digoxin toxicity published in 2004, how did the researchers decide when to administer the intervention drug (either CaCl or NS)? When they saw changes on the ECG consistent with hyperkalemia appeared [defined as doubling of either T-wave height or…

In a prospective study looking at yellow oleander published in 2019, what were the independent predictors of mortality? Larger number of seeds and hypotension Anandhi D, Pandit VR, Kadhiravan T, Soundaravally R, Raju KNJP. Cardiac arrhythmias, electrolyte abnormalities and serum cardiac glycoside concentrations in yellow…

In the ATOM-6 study, did giving of smaller, titratable doses of digoxin specific antibodies, increase the frequency of redosing of digoxin specific antibodies? Yes Chan BS, Isbister GK, Chiew A, Isoardi K, Buckley NA. Clinical experience with titrating doses of digoxin antibodies in acute digoxin…

Which parts of the yew plant are toxic? The leaves, seeds, and bark (excluding the red pulp) are poisonous and have active toxic metabolites. Alarfaj M, Goswami A. Cardiotoxicity in yew berry poisoning. Am J Emerg Med. 2021 Dec;50:812.e1-812.e4. doi: 10.1016/j.ajem.2021.05.043. Epub 2021 May 18….

Historical QOD 3/24/09: Which herbal medications may be associated with the development of hyperkalemia? Noni juice, alfalfa, dandelion, horsetail, nettle, milkweed, and hawthorne berries. (J Intensive Care Med, 2005 Sep 1, 20(5):272-290)

Sixty-one infants were divided into three groups in a blinded crossover trial, and each group received one of three eyedrops (cyclopentolate, phenylephrine, or tropicamide) for the purpose of dilating the pupil for an exam.  Each infant was seen on two different occasions and were either…

A randomized, single-blinded, placebo-controlled trial was conducted in Africa to evaluate the treatment of patients with aluminum phosphide poisoning. All patients received standard treatment, including primary resuscitation (airway, breathing, and circulation), intravenous fluids, vasopressors (norepinephrine), gastric decontamination (with sodium bicarbonate and activated charcoal at a…

A single center, retrospective cohort study of paracetamol ingestion was conducted in an institution that implemented a medical toxicology service. What was the difference in length of stay before the implementation of the toxicology service compared to after? The pre-toxicology service cohort had an average…

Social media challenges involving ingestion of diphenhydramine, laundry pods, nutmeg and cinnamon were associated with increases of reported ingestions to America’s Poison Centers National Poison Data System (NPDS). How long after Google Trends showed a peak did the number of reported ingestions with suicidal intent…

Historical QOD 3/23/09:  What pharmacologically based public-health measure may reduce the risk of arsenic-induced skin lesions in countries (such as Bangladesh) with high concentrations of arsenic in well water? B vitamins and antioxidants. (Environ Health Perspect, 2008 Aug, 116(8):1056-1062)