Question of the Day – Wednesday January 13, 2021
Phenazopyridine is metabolized to this metabolite that is presumed to play a contributory role for persistent, recurring methemoglobinemia after large doses of phenazopyridine. Aniline. After therapeutic doses, approximately 8% of phenazopyridine is metabolized to aniline. However, in overdoses, these authors theorize that this percentage is…
Question of the Day – Tuesday January 12, 2021
This excipient is believed to be the cause of lactic acidosis after chronic topical application of silver suladiazene. Propylene Glycol. Willis MS et al. Persistent lactic acidosis after chronic topical application of silver sulfadiazine in a pediatric burn patient: a review of the literature….
Question of the Day – Monday January 11, 2021
What hematologic toxicity may result from the use of henna? A recent case describes profound hemolysis in an elderly gentleman who had been prescribed henna powder dissolved in water for a GI ailment. Subsequent testing after recovery demonstrated normal G6PD activity. Naturally occurring henna…
Question of the Day – Friday January 8, 2021
This drug, when abused chronically causes hemorrhagic ulcerative cystitis, but has been investigated in animal models for prevention of ifofsamide induced hemorrhagic cystitis. Ketamine. In a rat study, a single dose of ketamine combined with mesna in ifosfamide exposed rats showed that ketamine alone prevented…
Question of the Day – Thursday January 7, 2021
Hemorrhagic cystitis occurs in 40-60% of patients receiving cyclophosphamide therapy. Name the causative xenobiotic. Name the drug that is often given to reduce this. 1. Acrolein. 2. Mesna. Mesna is given with either cyclophosphamide or ifofsamide to reduce hemorrhagic cystitis however the data on the…
EAPCCT 2021, Virtual Congress 25 to 28 May 2021 is underway!
EAPCCT Congress 2021 – an update! Planning for the EAPCCT’s first completely virtual congress to be held near you (!) in late May 2021 is now well underway. Your abstracts are under review, and Lotte Høgberg is gamely working to solve the extremely complex puzzle…
Question of the Day – Wednesday January 6, 2021
A child is found eating berries from a Tutu. What is the expected toxicity? Seizures. There are about 30 species of Coriariaceae in the world and the primary toxin is tutin. Tutin is structurally similar to picrotoxinin, the active component of picrotoxin which subsequently…
AACT in the Militiary
I’m most thankful for the personal connections that I’ve made during my military service. The friends and colleagues that I’ve made over the last 20 years are steadfast. They’re always there to help me solve leadership challenges, complex clinical problems, or any other issue that…
Question of the Day – Tuesday January 5, 2021
A patient is found unresponsive in his closet with the doors sealed shut and a sign that says “Do not enter”. Empty bottles of formic acid and sulfuric acid were next to the patient. What is the likely toxin? Carbon Monoxide. Carbon monoxide is formed…
Question of the Day – Monday January 4, 2021
What is the clinically relevant metabolic pathway of the toxin produced by Claviceps Purpurae? Ergotamines are CYP3A4 substrates. In combination with inhibitors of CYP3A4, such as antiretrovirals used to treat HIV, life and limb threatening vasospasm can result. Fröhlich G, Kaplan V, Amann-Vesti…