What phytomenadione dose/dose frequency was required to gain adequate coagulation control in brodifacoum adulterated synthetic cannabinoids exposures in Israel? What was the goal for coagulation control?
Phytomenadione 20 mg Q8h, aiming for an INR < 1.5
Lurie Y., Nadir Y., Hoffman R, et. al (2023). An outbreak of severe coagulopathy in northern Israel among users of illicit synthetic cannabinoids adulterated with brodifacoum. Clinical Toxicology, 61(6), 429–435. https://doi.org/10.1080/15563650.2023.2215402
Contributed by Herbert Wan, PharmD, PGY1 Toxicology/Emergency Medicine Fellow, FL/USVI Poison Information Center Jacksonville
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