Historical QOD 1/16/09: Describe the physiologic mechanism theorized to be at play in drug-associated extrapyramidal reactions.
The extrapyramidal system modulates motor function via excitatory cholinergic and inhibitory dopaminergic neurotransmission. Certain medications, including neuroleptics and some antiemetics, cause dopaminergic blockade, thus interfering with proper modulation of this motor system, leading to extrapyramidal motor effects.
Dingli K. Morgan R. Leen C. Acute dystonic reaction caused by metoclopramide, versus tetanus. BMJ. 334(7599):899-900, 2007 Apr 28.
Contributed by: M Greenberg
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